Progressive divergence of definitive haematopoietic stem cells from the endothelial compartment does not depend on contact with the foetal liver.

@article{Taoudi2005ProgressiveDO,
  title={Progressive divergence of definitive haematopoietic stem cells from the endothelial compartment does not depend on contact with the foetal liver.},
  author={Samir Taoudi and Aline M Morrison and Hirofumi Inoue and Ruby Gribi and Janice Ure and Alexander Medvinsky},
  journal={Development},
  year={2005},
  volume={132 18},
  pages={4179-91}
}
The yolk sac and the para-aortic splanchnopleura/aorta-genital ridges-mesonephros (P-Sp/AGM) region are the main sites of haematopoietic activity in the mouse embryo at the pre-liver stage of development. By day 11.5 of gestation, the AGM region is capable of autonomous initiation and expansion of definitive haematopoietic stem cells (HSCs). By day 12.5, HSC activity in the AGM region is reduced whilst a second wave of HSCs begins to emerge in the yolk sac. We show here that HSCs emerging in… CONTINUE READING