Progressive disorganization of the excitation-contraction coupling apparatus in aging human skeletal muscle as revealed by electron microscopy: a possible role in the decline of muscle performance.

@article{Boncompagni2006ProgressiveDO,
  title={Progressive disorganization of the excitation-contraction coupling apparatus in aging human skeletal muscle as revealed by electron microscopy: a possible role in the decline of muscle performance.},
  author={Simona Boncompagni and Luigi d'Amelio and Stefania Fulle and Giorgio Fan{\'o} and Feliciano Protasi},
  journal={The journals of gerontology. Series A, Biological sciences and medical sciences},
  year={2006},
  volume={61 10},
  pages={995-1008}
}
An impairment of the mechanisms controlling the release of calcium from internal stores (excitation-contraction [EC] coupling) has been proposed to contribute to the age-related decline of muscle performance that accompanies aging (EC uncoupling theory). EC coupling in muscle fibers occurs at the junctions between sarcoplasmic reticulum and transverse tubules, in structures called calcium release units (CRUs). We studied the frequency, cellular localization, and ultrastructure of CRUs in human… CONTINUE READING