Progressive derailment of cell cycle regulators in endometrial carcinogenesis.

  title={Progressive derailment of cell cycle regulators in endometrial carcinogenesis.},
  author={Nicole Horr{\'e}e and Paul J van Diest and Petra van der Groep and Daisy M. D. S. Sie-Go and A. Peter M. Heintz},
  journal={Journal of clinical pathology},
  volume={61 1},
BACKGROUND Derailments of the control mechanisms of the cell cycle can initiate carcinogenesis, and play a role in progression to cancer. AIM To explore the expression of cell cycle proteins in normal, premalignant and malignant endometrial lesions representing the morphologically well defined stepwise model of human endometrial carcinogenesis METHODS Observational study. Paraffin-embedded specimens from inactive endometrium (n = 16), endometrial hyperplasia (n = 23) and endometrioid… CONTINUE READING


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