Progressive degeneration of human neural stem cells caused by pathogenic LRRK2

  title={Progressive degeneration of human neural stem cells caused by pathogenic LRRK2},
  author={Guang-Hui Liu and Jing Qu and Keiichiro Suzuki and Emmanuel Nivet and Mo Li and N{\'u}ria Gass{\'o} Montserrat and Fei Yi and Xiuling Xu and Sergio Ruiz and Weiqi Zhang and Bing Ren and Ulrich Wagner and Audrey Kim and Ying Li and April Goebl and Jessica Kim and Rupa Devi Soligalla and Ilir Dubova and James X. Thompson and John R. Yates and Concepci{\'o}n Rodr{\'i}guez Esteban and Ignacio Sancho-Martinez and Juan Carlos Izpisua Belmonte},
Nuclear-architecture defects have been shown to correlate with the manifestation of a number of human diseases as well as ageing. It is therefore plausible that diseases whose manifestations correlate with ageing might be connected to the appearance of nuclear aberrations over time. We decided to evaluate nuclear organization in the context of ageing-associated disorders by focusing on a leucine-rich repeat kinase 2 (LRRK2) dominant mutation (G2019S; glycine-to-serine substitution at amino acid… CONTINUE READING