Progressive damage of cultured pancreatic islets after single early exposure to streptozocin.

@article{Bolaffi1986ProgressiveDO,
  title={Progressive damage of cultured pancreatic islets after single early exposure to streptozocin.},
  author={Janice L. Bolaffi and R E Nowlain and Luis Alejandro Riveros Cruz and Gerold M. Grodsky},
  journal={Diabetes},
  year={1986},
  volume={35 9},
  pages={1027-33}
}
To examine effects of streptozocin (STZ) on pancreatic islets in the absence of a functioning immune system, we examined isolated rat islets cultured for 96 h after a single 1-h exposure to STZ in vitro. In addition to an immediate and sustained suppression of insulin secretion, STZ also induced a progressive decline in insulin content per islet as well as in total islet tissue mass, characterized by a decrease in both islet number and volume. Viability studies show that STZ-induced cell death… CONTINUE READING

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