Progressive cross-linking of fibrin gamma chains increases resistance to fibrinolysis.

Abstract

In the presence of plasma transglutaminase (factor XIIIa) fibrin first undergoes intermolecular covalent cross-linking between its gamma chains to create gamma dimers followed by slower cross-linking among its alpha chains to form alpha polymers. Progressive cross-linking of gamma chain dimers occurs at the slowest rate, resulting in gamma trimers and gamma… (More)

Topics

Cite this paper

@article{Siebenlist1994ProgressiveCO, title={Progressive cross-linking of fibrin gamma chains increases resistance to fibrinolysis.}, author={Kevin R. Siebenlist and Michael W. Mosesson}, journal={The Journal of biological chemistry}, year={1994}, volume={269 45}, pages={28414-9} }