Progressive chondrocyte death after impact injury indicates a need for chondroprotective therapy.

@article{Szczodry2009ProgressiveCD,
  title={Progressive chondrocyte death after impact injury indicates a need for chondroprotective therapy.},
  author={Michal Szczodry and Christian H. Coyle and Scott James Kramer and Patrick Smolinski and Constance R. Chu},
  journal={The American journal of sports medicine},
  year={2009},
  volume={37 12},
  pages={2318-22}
}
BACKGROUND Impact injury to articular cartilage can lead to posttraumatic osteoarthritis. HYPOTHESES This study tests the hypotheses that (1) chondrocyte injury occurs after impact at energies insufficient to fracture the cartilage surface, and that (2) cartilage injury patterns vary with impact energy, time after injury, and cartilage thickness. STUDY DESIGN Controlled laboratory study. METHODS Fresh bovine osteochondral cores were randomly divided into 5 groups: (1) control, (2) 0.35 J… CONTINUE READING

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