Progressive changes in pneumococcal carriage in children attending daycare in Portugal after 6 years of gradual conjugate vaccine introduction show falls in most residual vaccine serotypes but no net replacement or trends in diversity.

@article{Rodrigues2012ProgressiveCI,
  title={Progressive changes in pneumococcal carriage in children attending daycare in Portugal after 6 years of gradual conjugate vaccine introduction show falls in most residual vaccine serotypes but no net replacement or trends in diversity.},
  author={Fernanda Rodrigues and Dona Foster and Francisco Caramelo and Pedro Serranho and Guilherme Gonçalves and Lu{\'i}s Janu{\'a}rio and Adam Finn},
  journal={Vaccine},
  year={2012},
  volume={30 26},
  pages={
          3951-6
        }
}
OBJECTIVES To track ongoing trends in pneumococcal (Sp) serotype carriage under the selection pressure of moderate pneumococcal conjugate vaccine (PCV) use, children in a community in Portugal were studied in the same months in 3 consecutive years. METHODS Nasopharyngeal specimens were collected (children aged 3 months to <7 years) in 8 urban daycare centers in February 2008 (n=561) and 2009 (n=585). Sp isolates were serotyped. RESULTS While demographics were similar in 2008-2009 and a… CONTINUE READING

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