Progressive changes in Met-dependent signaling in a human ovarian surface epithelial model of malignant transformation.

@article{Wong2004ProgressiveCI,
  title={Progressive changes in Met-dependent signaling in a human ovarian surface epithelial model of malignant transformation.},
  author={Alice S T Wong and Calvin D Roskelley and Steven Pelech and Dianne Miller and Peter C. K. Leung and Nelly Auersperg},
  journal={Experimental cell research},
  year={2004},
  volume={299 1},
  pages={248-56}
}
We used an experimental in vitro model of human ovarian surface epithelium (OSE), the tissue of origin of >90% of ovarian cancers, to more precisely define the contribution of hepatocyte growth factor (HGF) to various OSE phenotypes at different stages of neoplastic progression. Neoplastic transformation of OSE in cultures was achieved by multiple genetic manipulations, resulting in the nontumorigenic line IOSE-29, the tumorigenic IOSE-Ov29, and the tumor-derived, more highly malignant IOSE… CONTINUE READING

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