Progressive but previously untreated CLL patients with greater array CGH complexity exhibit a less durable response to chemoimmunotherapy.

@article{Kay2010ProgressiveBP,
  title={Progressive but previously untreated CLL patients with greater array CGH complexity exhibit a less durable response to chemoimmunotherapy.},
  author={Neil E Kay and Jeanette E. Eckel-Passow and Esteban Braggio and Scott Vanwier and Tait D Shanafelt and Daniel L Van Dyke and Diane F. Jelinek and Renee C. Tschumper and Thomas J. Kipps and John C. Byrd and Rafael Fonseca},
  journal={Cancer genetics and cytogenetics},
  year={2010},
  volume={203 2},
  pages={161-8}
}
To better understand the implications of genomic instability and outcome in B-cell chronic lymphocytic leukemia (CLL), we sought to address genomic complexity as a predictor of chemosensitivity and ultimately clinical outcome in this disease. We used array-based comparative genomic hybridization (aCGH) with a one-million probe array and identified gains and losses of genetic material in 48 patients treated on a chemoimmunotherapy clinical trial. We identified chromosomal gain or loss in ≥6% of… CONTINUE READING

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