Progressive brain volume loss in schizophrenia over the course of the illness: evidence of maturational abnormalities in early adulthood.

@article{Haren2008ProgressiveBV,
  title={Progressive brain volume loss in schizophrenia over the course of the illness: evidence of maturational abnormalities in early adulthood.},
  author={Neeltje E.M . van Haren and Hilleke E. Hulshoff Pol and Hugo G. Schnack and Wiepke Cahn and Rachel G. H. Brans and Inge Carati and Monica Rais and Ren{\'e} S. Kahn},
  journal={Biological psychiatry},
  year={2008},
  volume={63 1},
  pages={106-13}
}
BACKGROUND Considering the magnitude of the reported changes in brain volume over time in first-episode patients it is unlikely that these changes are constant over the life-span of the schizophrenic illness. Thus, one would expect the progression in brain volume change in schizophrenia to follow a more complex trajectory over time. METHODS Two magnetic resonance imaging brain scans were obtained over a 5-year interval of 96 schizophrenia patients and 113 healthy subjects between ages 16 to… CONTINUE READING

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