Progressive age-related changes in sleep and EEG profiles in the PLB1Triple mouse model of Alzheimer's disease.


Sleep disturbances are common in Alzheimer's disease (AD) and now assumed to contribute to disease onset and progression. Here, we investigated whether activity, sleep/wake pattern, and electroencephalogram (EEG) profiles are altered in the knock-in PLB1Triple mouse model from 5 to 21 months of age. PLB1Triple mice displayed a progressive increase in… (More)
DOI: 10.1016/j.neurobiolaging.2015.07.001


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