Progressive adriamycin nephropathy in mice: sequence of histologic and immunohistochemical events.

@article{Wang2000ProgressiveAN,
  title={Progressive adriamycin nephropathy in mice: sequence of histologic and immunohistochemical events.},
  author={Yiping Wang and Yong Ping Wang and Yee Chen Tay and David Charles Hamlyn Harris},
  journal={Kidney international},
  year={2000},
  volume={58 4},
  pages={1797-804}
}
BACKGROUND As an experimental analogue of human focal glomerular sclerosis (FGS), adriamycin (ADR)-induced nephropathy is well-characterized in rats. Previously, this model has not been fully established in mice. The extension of this model to the mouse would be useful in the application of genetic and monoclonal antibody technology to characterize mechanisms of progressive renal disease. Herein, we describe a stable and reproducible murine model of chronic proteinuria induced by ADR. METHODS… CONTINUE READING
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