Progressive activation of CyclinB1-Cdk1 coordinates entry to mitosis.

@article{Gavet2010ProgressiveAO,
  title={Progressive activation of CyclinB1-Cdk1 coordinates entry to mitosis.},
  author={Olivier Gavet and Jonathon Pines},
  journal={Developmental cell},
  year={2010},
  volume={18 4},
  pages={533-43}
}
The CyclinB1-Cdk1 kinase is the catalytic activity at the heart of mitosis-promoting factor (MPF), yet fundamental questions concerning its role in mitosis remained unresolved. It is not known when and how rapidly CyclinB1-Cdk1 is activated in mammalian cells, nor how its activation coordinates the substantial changes in the cell at mitosis. Here, we have… CONTINUE READING