Progressive action potential duration shortening and the conversion from atrial flutter to atrial fibrillation in the isolated canine right atrium.

Abstract

OBJECTIVES We sought to evaluate the effects of progressive shortening of the action potential duration (APD) on atrial wave front stability. BACKGROUND The mechanisms of conversion from atrial flutter to atrial fibrillation (AF) are unclear. METHODS Isolated canine right atria were perfused with 1 to 5 micromol/l of acetylcholine (ACh). We mapped the… (More)

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