Progressive Visceral Leishmaniasis Is Driven by Dominant Parasite-induced STAT6 Activation and STAT6-dependent Host Arginase 1 Expression

@inproceedings{Osorio2012ProgressiveVL,
  title={Progressive Visceral Leishmaniasis Is Driven by Dominant Parasite-induced STAT6 Activation and STAT6-dependent Host Arginase 1 Expression},
  author={E Yaneth Osorio and Weiguo Zhao and Claudia O. Espitia and Omar A. Saldarriaga and Leo Hawel and Craig Vernon Byus and Bruno L Travi and Peter C Melby},
  booktitle={PLoS pathogens},
  year={2012}
}
The clinicopathological features of the hamster model of visceral leishmaniasis (VL) closely mimic active human disease. Studies in humans and hamsters indicate that the inability to control parasite replication in VL could be related to ineffective classical macrophage activation. Therefore, we hypothesized that the pathogenesis of VL might be driven by a program of alternative macrophage activation. Indeed, the infected hamster spleen showed low NOS2 but high arg1 enzyme activity and protein… CONTINUE READING

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