Progressive Staging of Pilot Studies to Improve Phase III Trials for Motor Interventions.

@article{Dobkin2009ProgressiveSO,
  title={Progressive Staging of Pilot Studies to Improve Phase III Trials for Motor Interventions.},
  author={Bruce Dobkin},
  journal={Neurorehabilitation and neural repair},
  year={2009},
  volume={23 3},
  pages={197-206}
}
Based on the suboptimal research pathways that finally led to multicenter randomized clinical trials (MRCTs) of treadmill training with partial body weight support and of robotic assistive devices, strategically planned successive stages are proposed for pilot studies of novel rehabilitation interventions. Stage 1, consideration-of-concept studies, drawn from animal experiments, theories, and observations, delineate the experimental intervention in a small convenience sample of participants, so… CONTINUE READING

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