Progressive Reduction of its Expression in Rods Reveals Two Pools of Arrestin-1 in the Outer Segment with Different Roles in Photoresponse Recovery

@inproceedings{Cleghorn2011ProgressiveRO,
  title={Progressive Reduction of its Expression in Rods Reveals Two Pools of Arrestin-1 in the Outer Segment with Different Roles in Photoresponse Recovery},
  author={Whitney M. Cleghorn and Elviche L. Tsakem and Xiufeng Song and Sergey A. Vishnivetskiy and Jungwon Seo and Jeannie Chen and Eugenia V Gurevich and Vsevolod V. Gurevich},
  booktitle={PloS one},
  year={2011}
}
Light-induced rhodopsin signaling is turned off with sub-second kinetics by rhodopsin phosphorylation followed by arrestin-1 binding. To test the availability of the arrestin-1 pool in dark-adapted outer segment (OS) for rhodopsin shutoff, we measured photoresponse recovery rates of mice with arrestin-1 content in the OS of 2.5%, 5%, 60%, and 100% of wild type (WT) level by two-flash ERG with the first (desensitizing) flash at 160, 400, 1000, and 2500 photons/rod. The time of half recovery (t… CONTINUE READING

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