Progressive Dopaminergic Degeneration in the Chronic MPTPp Mouse Model of Parkinson’s Disease

@article{Schintu2009ProgressiveDD,
  title={Progressive Dopaminergic Degeneration in the Chronic MPTPp Mouse Model of Parkinson’s Disease},
  author={Nicoletta Schintu and Lucia Frau and Marcello Ibba and Arianna Garau and Ezio Carboni and Anna R Carta},
  journal={Neurotoxicity Research},
  year={2009},
  volume={16},
  pages={127-139}
}
Parkinson’s disease (PD) is characterized by a progressive degeneration of dopamine (DA) neurons and gradual worsening of motor symptoms. The investigation of progressive degenerative mechanisms and potential neuroprotective strategies relies on experimental models of the chronic neuropathology observed in human. The present study investigated the progressive nature of neurodegeneration in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine/probenecid (MPTPp) chronic mouse model of PD. MPTP (25 mg… CONTINUE READING