Progressive Chromatin Condensation and H3K9 Methylation Regulate the Differentiation of Embryonic and Hematopoietic Stem Cells

@inproceedings{Ugarte2015ProgressiveCC,
  title={Progressive Chromatin Condensation and H3K9 Methylation Regulate the Differentiation of Embryonic and Hematopoietic Stem Cells},
  author={Fernando Ugarte and Rebekah Sousae and Bertrand P. Cinquin and Eric W. Martin and Jana Krietsch and Gabriela Jimenez Zeron Sanchez and Margaux Inman and Herman Tsang and Matthew R. Warr and Emmanuelle Passegu{\'e} and Carolyn A Larabell and E. Camilla Forsberg},
  booktitle={Stem cell reports},
  year={2015}
}
Epigenetic regulation serves as the basis for stem cell differentiation into distinct cell types, but it is unclear how global epigenetic changes are regulated during this process. Here, we tested the hypothesis that global chromatin organization affects the lineage potential of stem cells and that manipulation of chromatin dynamics influences stem cell function. Using nuclease sensitivity assays, we found a progressive decrease in chromatin digestion among pluripotent embryonic stem cells… CONTINUE READING
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ROBO 4 - mediated vascular integrity regulates the direction - 740 Stem Cell Reports j

  • S. Smith-Berdan, A. Nguyen, M. A. Hong, E. C. Forsberg
  • Stem Cell Reports
  • 2015
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