Progressive CD4+ central–memory T cell decline results in CD4+ effector–memory insufficiency and overt disease in chronic SIV infection

@article{Okoye2007ProgressiveCC,
  title={Progressive CD4+ central–memory T cell decline results in CD4+ effector–memory insufficiency and overt disease in chronic SIV infection},
  author={Afam A. Okoye and Martin Meier-Schellersheim and Jason M. Brenchley and Shoko I. Hagen and Joshua M. Walker and Mukta Rohankhedkar and Richard Lum and John B. Edgar and Shannon L. Planer and Alfred W. Legasse and Andrew W. Sylwester and Michael J. Piatak and Jeffrey D Lifson and Vernon C. Maino and Donald L Sodora and Daniel C. Douek and Michael K Axthelm and Z. Grossman and Louis J. Picker},
  journal={The Journal of Experimental Medicine},
  year={2007},
  volume={204},
  pages={2493 - 2493}
}
Primary simian immunodeficiency virus (SIV) infections of rhesus macaques result in the dramatic depletion of CD4(+) CCR5(+) effector-memory T (T(EM)) cells from extra-lymphoid effector sites, but in most infections, an increased rate of CD4(+) memory T cell proliferation appears to prevent collapse of effector site CD4(+) T(EM) cell populations and acute-phase AIDS. Eventually, persistent SIV replication results in chronic-phase AIDS, but the responsible mechanisms remain controversial. Here… CONTINUE READING
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