Progression to AIDS in South Africa Is Associated with both Reverting and Compensatory Viral Mutations

@inproceedings{Huang2011ProgressionTA,
  title={Progression to AIDS in South Africa Is Associated with both Reverting
                    and Compensatory Viral Mutations},
  author={Kuan-Hsiang Gary Huang and Dominique Goedhals and Jonathan M. Carlson and Mark A Brockman and Swati Mishra and Zabrina L. Brumme and Stephen Hickling and Christopher S. Tang and Toshiyuki Miura and Chris J Seebregts and David Heckerman and Thumbi Ndung'u and Bruce D. Walker and Paul Klenerman and Dewald Steyn and Philip Jeremy Renshaw Goulder and Rodney Phillips and Cloete van Vuuren and John A. Frater},
  booktitle={PloS one},
  year={2011}
}
We lack the understanding of why HIV-infected individuals in South Africa progress to AIDS. We hypothesised that in end-stage disease there is a shifting dynamic between T cell imposed immunity and viral immune escape, which, through both compensatory and reverting viral mutations, results in increased viral fitness, elevated plasma viral loads and disease progression. We explored how T cell responses, viral adaptation and viral fitness inter-relate in South African cohorts recruited from… CONTINUE READING
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