Progression of vertebral fractures despite long-term biochemical control of acromegaly: a prospective follow-up study.

@article{Claessen2013ProgressionOV,
  title={Progression of vertebral fractures despite long-term biochemical control of acromegaly: a prospective follow-up study.},
  author={Kim M. J. A. Claessen and Herman M. Kroon and Alberto M Pereira and Natasha M. Appelman-Dijkstra and Marco J. T. Verstegen and Margreet Kloppenburg and N A Hamdy and Nienke R Biermasz},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2013},
  volume={98 12},
  pages={4808-15}
}
BACKGROUND In active acromegaly, pathologically elevated GH and IGF-1 levels are associated with increased bone turnover and a high bone mass, the latter being sustained after normalization of GH values. In a cross-sectional study design, we have previously reported a high prevalence of vertebral fractures (VFs) of about 60% in patients with controlled acromegaly, despite normal mean bone mineral density (BMD) values. Whether these fractures occur during the active acromegaly phase or after… CONTINUE READING
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