Progression of type 2 diabetes in GK rats affects muscle and liver mitochondria differently: pronounced reduction of complex II flux is observed in liver only.

@article{Jrgensen2012ProgressionOT,
  title={Progression of type 2 diabetes in GK rats affects muscle and liver mitochondria differently: pronounced reduction of complex II flux is observed in liver only.},
  author={Wenche J{\o}rgensen and Peter Jelnes and Kasper Abildgaard Rud and Lillian H. L. Hansen and Niels Grunnet and Bj{\o}rn Grunnet Quistorff},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2012},
  volume={303 4},
  pages={
          E515-23
        }
}
Impaired mitochondrial function is implicated in the development of type 2 diabetes mellitus (T2DM). This was investigated in mitochondria from skeletal muscle and liver of the Goto-Kakizaki (GK) rat, which spontaneously develops T2DM with age. The early and the manifest stage of T2DM was studied in 6- and 16-wk-old GK rats, respectively. In GK16 compared with GK6 animals, a decrease in state 3 respiration with palmitoyl carnitine (PC) as substrate was observed in muscle. Yet an increase was… CONTINUE READING
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