Progression of the dose-related effects of estrogenic endocrine disruptors, an important factor in declining fertility, differs between the hypothalamo-pituitary axis and reproductive organs of male mice.

@article{Warita2006ProgressionOT,
  title={Progression of the dose-related effects of estrogenic endocrine disruptors, an important factor in declining fertility, differs between the hypothalamo-pituitary axis and reproductive organs of male mice.},
  author={Katsuhiko Warita and Teruo Sugawara and Zhan-Peng Yue and Shinji Tsukahara and Ken-ichiro Mutoh and Yoshihisa Hasegawa and Hiroshi Kitagawa and Chisato Mori and Nobuhiko Hoshi},
  journal={The Journal of veterinary medical science},
  year={2006},
  volume={68 12},
  pages={1257-67}
}
For the purpose of investigation of working mechanisms in endocrine disruptors, we evaluated the dose-related effects of fetal and/or neonatal exposure to an estrogenic compound on the male reproductive organs in adult mice, particularly with respect to gene expression of steroidogenic acute regulatory protein (StAR). The pregnant ICR mice were given subcutaneous injections of 10 micro g/day/animal of diethylstilbestrol (DES) to subject the fetal mice to in utero exposure (IUE). Subsequently… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 33 references

Devel - opmental toxicity ef estrogenic chemica ] s on rodents and other species

H. Watanabe, Y. Katsu, +5 authors H. Kato
Cengenit , Anom . ( kyoto ) • 2002

Localization of estrogen receptor cr , estrogen receptor P and androgen receptors in the rat reproductive ergan

C. Labrie, F. Labrie
J . Endocrinot . • 2000

Long - term effects of perinata ] exposure to sex steroids and diethylstilbestrol en the reproductive system of male marnmals

N. Atanassova, C. McKinnell, +3 authors R. M. Shurpe
2000

0 nteg - eny ef estrogen receptorS expression in rat testis

A. M. van Pelt, D de Reoij, +4 authors G. G. Kuiper
1999

Changes in the number , proliferation rate and bcl - 2 protein immunoexpression of epithelial and periductal cells from rat epididymis during postnatal development

R. Rarnirez, R. Martin, +3 authors L. Santamaria
J . Andrel . • 1999

Similar Papers

Loading similar papers…