Progression of renal insufficiency in type 2 diabetes with and without microalbuminuria: results of the Heart Outcomes and Prevention Evaluation (HOPE) randomized study.

@article{Mann2003ProgressionOR,
  title={Progression of renal insufficiency in type 2 diabetes with and without microalbuminuria: results of the Heart Outcomes and Prevention Evaluation (HOPE) randomized study.},
  author={Johannes F. E. Mann and Hertzel C. Gerstein and Qi-long Yi and Joerg Franke and Eva M. Lonn and Byron J Hoogwerf and Andrew M. Rashkow and Salim Yusuf},
  journal={American journal of kidney diseases : the official journal of the National Kidney Foundation},
  year={2003},
  volume={42 5},
  pages={936-42}
}
BACKGROUND In patients with type 2 diabetes with overt nephropathy, the risk for progressive renal failure is high. This risk is less well established for those with type 2 diabetes and microalbuminuria or normalbuminuria. We studied changes in serum creatinine levels during 3.5 to 5.5 years in a large cohort of people with diabetes at high cardiovascular risk with microalbuminuria or normalbuminuria. METHODS Retrospective analysis of serum creatinine levels at baseline and yearly thereafter… CONTINUE READING

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A doubling of baseline serum creatinine level or end - stage renal disease developed in 8 of 333 participants with renal insufficiency at baseline . CONCLUSION .
In people with type 2 diabetes , but without overt nephropathy , who are at high risk for cardiovascular disease , progression of renal insufficiency is slow on the basis of changes in creatinine levels .
In patients with type 2 diabetes with overt nephropathy , the risk for progressive renal failure is high .
A doubling of baseline serum creatinine level or end - stage renal disease developed in 8 of 333 participants with renal insufficiency at baseline . CONCLUSION .
In people with type 2 diabetes , but without overt nephropathy , who are at high risk for cardiovascular disease , progression of renal insufficiency is slow on the basis of changes in creatinine levels .
In patients with type 2 diabetes with overt nephropathy , the risk for progressive renal failure is high .
A doubling of baseline serum creatinine level or end - stage renal disease developed in 8 of 333 participants with renal insufficiency at baseline . CONCLUSION .
In patients with type 2 diabetes with overt nephropathy , the risk for progressive renal failure is high .
In people with type 2 diabetes , but without overt nephropathy , who are at high risk for cardiovascular disease , progression of renal insufficiency is slow on the basis of changes in creatinine levels .
A doubling of baseline serum creatinine level or end - stage renal disease developed in 8 of 333 participants with renal insufficiency at baseline . CONCLUSION .
In patients with type 2 diabetes with overt nephropathy , the risk for progressive renal failure is high .
In people with type 2 diabetes , but without overt nephropathy , who are at high risk for cardiovascular disease , progression of renal insufficiency is slow on the basis of changes in creatinine levels .
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