Progression of non-alcoholic steatosis to steatohepatitis and fibrosis parallels cumulative accumulation of danger signals that promote inflammation and liver tumors in a high fat–cholesterol–sugar diet model in mice

@inproceedings{Ganz2015ProgressionON,
  title={Progression of non-alcoholic steatosis to steatohepatitis and fibrosis parallels cumulative accumulation of danger signals that promote inflammation and liver tumors in a high fat–cholesterol–sugar diet model in mice},
  author={Michal Ganz and Terence Ndonyi Bukong and Timea Csak and Banishree Saha and Jin-Kyu Park and A. Sumit Ambade and Karen Kodys and Gyongyi Szabo},
  booktitle={Journal of Translational Medicine},
  year={2015}
}
Non-alcoholic fatty liver disease (NAFLD) is becoming a pandemic. While multiple ‘hits’ have been reported to contribute to NAFLD progression to non-alcoholic steatohepatitis (NASH), fibrosis and liver cancer, understanding the natural history of the specific molecular signals leading to hepatocyte damage, inflammation and fibrosis, is hampered by the lack of suitable animal models that reproduce disease progression in humans. The purpose of this study was first, to develop a mouse model that… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 5 times over the past 90 days. VIEW TWEETS
24 Extracted Citations
58 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 24 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 58 references

Similar Papers

Loading similar papers…