Progression of myelodysplastic syndrome: allelic loss on chromosomal arm 1p.

@article{Mori2003ProgressionOM,
  title={Progression of myelodysplastic syndrome: allelic loss on chromosomal arm 1p.},
  author={Naoki Mori and Roberta Morosetti and Hideaki Mizoguchi and H Phillip Koeffler},
  journal={British journal of haematology},
  year={2003},
  volume={122 2},
  pages={226-30}
}
Myelodysplastic syndrome (MDS) is a common neoplasm of haematopoietic pluripotent stem cells. Although one third of MDS patients evolve to acute myeloid leukaemia (AML), little is understood about the mechanisms responsible for this progression. We have previously detected the frequent loss of heterozygosity (LOH) on the short arm of chromosome 1 in blast crisis of chronic myelocytic leukaemia. In this study, we examined the chromosomal arm 1p for allelic loss in the progression of MDS to AML… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 23 extracted citations

Similar Papers

Loading similar papers…