Progression of human breast cancer cells from hormone-dependent to hormone-independent growth both in vitro and in vivo.

@article{Clarke1989ProgressionOH,
  title={Progression of human breast cancer cells from hormone-dependent to hormone-independent growth both in vitro and in vivo.},
  author={R Clarke and N Br{\"u}nner and Benita S Katzenellenbogen and E W Thompson and Michael Norman and C Koppi and S Paik and M E Lippman and Robert B. Dickson},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1989},
  volume={86 10},
  pages={3649-53}
}
  • R Clarke, N Brünner, +6 authors Robert B. Dickson
  • Published 1989 in
    Proceedings of the National Academy of Sciences…
We have isolated a series of sublines of the hormone-dependent MCF-7 human breast cancer cell line after selection both in vivo and in vitro for growth in the presence of subphysiological concentrations of estrogens. These sublines represent a model system for study of the processes leading to hormonal autonomy. The cells form growing tumors in ovariectomized athymic nude mice in the absence of estrogen supplementation but retain some responsivity to estrogen as determined by stimulation of the… CONTINUE READING