Progression of fibrosis in chronic hepatitis C.

  title={Progression of fibrosis in chronic hepatitis C.},
  author={Marc G Ghany and David E Kleiner and Harvey Alter and Edward C Doo and Farooq Khokar and Kittichai Promrat and David Herion and Yoon Park and Tehming Liang and Jay H. Hoofnagle},
  volume={124 1},
BACKGROUND & AIMS Fibrosis is the hallmark of hepatic cirrhosis, worsening of which is probably the best surrogate marker for progression of chronic liver disease. We evaluated a large cohort of patients with chronic hepatitis C (CHC) using liver histology to assess the rate and predictors of progression of fibrosis. METHODS The cohort consisted of 123 patients with CHC who underwent 2 liver biopsies 4-212 months (mean, 44 months) apart without intervening treatment. Liver histology was… CONTINUE READING


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