Progression of conservatively treated endometrial carcinoma after full term pregnancy: a case report.

Abstract

INTRODUCTION We describe a case of conservatively treated endometrial endometrioid (EE) adenocarcinoma which showed an aggressive clinical outcome after pregnancy. CASE A 30-year-old woman with a well differentiated EE adenocarcinoma decided to attempt a conservative approach and underwent progestin treatment with subsequent negative ultrasound and hysteroscopic controls. After 3 months, she conceived and at 36 weeks of gestation, a cesarean section was performed with multiple negative biopsies. Eight 8 months after delivery, an exploratory laparotomy documented disseminated poorly differentiated EE adenocarcinoma. Staging work up revealed diffuse metastatic disease. Despite chemotherapy, the patient experienced progression of disease with fatal acute respiratory syndrome due to massive neoplastic pulmonary lymphangitis. CONCLUSION Conservative medical management of endometrial cancer in young women willing to preserve their reproductive potential, carries on potential risks. Careful selection of cases, informed consent, and strict follow up procedures are mandatory.

Statistics

0502008200920102011201220132014201520162017
Citations per Year

103 Citations

Semantic Scholar estimates that this publication has 103 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Ferrandina2005ProgressionOC, title={Progression of conservatively treated endometrial carcinoma after full term pregnancy: a case report.}, author={Gabriella Ferrandina and Gian Franco Zannoni and Valerio Gallotta and Elvira Foti and Salvatore Mancuso and Giovanni Scambia}, journal={Gynecologic oncology}, year={2005}, volume={99 1}, pages={215-7} }