Progression of clinical signs in severe infant botulism. Therapeutic implications.

  title={Progression of clinical signs in severe infant botulism. Therapeutic implications.},
  author={Charles S L'Hommedieu and Richard A. Polin},
  journal={Clinical pediatrics},
  volume={20 2},
The clinical evaluation of nine patients with severe infant botulism revealed an identifiable progression of signs due to blockade of the cholinergic synapse similar to that described for competitive blocking agents. This predictable sequence reflects different "margins of safety" for muscles involved in repetitive activities, diaphragmatic function and movement of the extremities. It is important for the clinician to realize that return of peripheral motor activity does not signify a… CONTINUE READING

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