Progression of change following median nerve section in the cortical representation of the hand in areas 3b and 1 in adult owl and squirrel monkeys

  title={Progression of change following median nerve section in the cortical representation of the hand in areas 3b and 1 in adult owl and squirrel monkeys},
  author={M. M. Merzenich and Jon H. Kaas and John Wall and Mriganka Sur and Randall Nelson and D. J. Felleman},

Reorganization of Somatosensory Cortical Areas 3b and 1 after Unilateral Section of Dorsal Columns of the Spinal Cord in Squirrel Monkeys

The results indicate that extensive reactivations of the hand representations in cortical areas 3b and 1 occur contralateral to the spinal cord lesion, even when <1% of labeled dorsal column terminations in the cuneate nucleus remained.

Functional reorganization in somatosensory cortical areas 3b and 1 of adult monkeys after median nerve repair: possible relationships to sensory recovery in humans

The results suggest that nerve regeneration reestablishes the cortical capacity to process tactile information from reinnervated skin via a prolonged reorganizational process that appears dependent on peripheral and central factors.

Large-Scale Reorganization in the Somatosensory Cortex and Thalamus after Sensory Loss in Macaque Monkeys

A comparison of the extents of deafferentation across the monkeys shows that even if the dorsal column lesion is partial, preserving most of the hand representation, it is sufficient to induce an expansion of the face representation.

Receptor autoradiographic correlates of deafferentation‐induced reorganization in adult primate somatosensory cortex

The primate somatosensory system provides an excellent model system with which to investigate adult neural plasticity. We have previously shown that transection of the median and ulnar nerves is

Sensitivity of neurons in somatosensory cortex (S1) to cutaneous stimulation of the hindlimb immediately following a sciatic nerve crush.

While a large number of studies have examined receptive field alterations in the cerebral cortex after peripheral nerve injury, descriptions of neuronal sensitivity have been largely qualitative. In

Initial cortical reactions to injury of the median and radial nerves to the hands of adult primates

These rapid expansions are a beginning point from which further changes must progress; however, in contrast to changes accompanying chronic hand injuries, these initial cortical reactions do not appear dictated by use of uninjured inputs.

Patterns of cortical reorganization in the adult marmoset after a cervical spinal cord injury

Results indicate that areas 3a, 3b, 1, and 2–5 of the somatosensory cortex are extensively reactivated after large, apparently complete lesions of the contralateral cuneate fasciculus, but afferents from the digits may not contribute to their reactivation.

Evidence for Brainstem and Supra-Brainstem Contributions to Rapid Cortical Plasticity in Adult Monkeys

Results indicate that cuneate tactile responsiveness, receptive field locations, somatotopic organization, and spatial properties of representations change during the first minutes to hours after injury, and provide evidence that rapid reorganization in area 3b, in part, reflects mechanisms that operate from a distance in the cuneating nucleus.

Plasticity in cerebellar tactile maps in the adult rat

The data show that, although both afferent pathways are capable of reorganization throughout development, their relative contribution to the map appears to differ, depending on the age at which lesion occurs.



Time-dependent changes in the functional organization of somatosensory cerebral cortex following digit amputation in adult raccoons.

The combined results of these experiments indicate that within 36 weeks following removal of a digit in raccoons, the deprived SmI cortical sector undergoes a dynamic sequence of changes in functional organization.

Connections of the ventroposterior nucleus of the thalamus with the body surface representations in cortical areas 3b and 1 of the cynomolgus macaque, (Macaca fascicularis)

The somatotopic pattern of the connections of the ventroposterior nucleus of the thalamus with the representations of the body surface in somatic cortical Areas 3b and 1 were investigated in macaque

Reorganization of raccoon somatosensory cortex following removal of the fifth digit

The organization of part of the primary somatosensory cortex was examined in anesthetized raccoons at 2, 8, or 16 weeks after the normal peripheral input to this region of cortex had been removed by amputation of the fifth digit, suggestive of extensive anatomical changes either within the cortex itself or at subcortical levels.

Magnification, receptive-field area, and "hypercolumn" size in areas 3b and 1 of somatosensory cortex in owl monkeys.

The area of cortex presumed to receive all fibers from any given receptive field was obtained and found to be independent of the body surface represented and may be akin to the “hypercolumn” proposed for primary visual cortex.

Representations of the body surface in postcentral parietal cortex of Macaca fascicularis

The somatotopic organization of the postcentral parietal cortex of the Old World monkey, Macaca fascicularis, was determined with multi‐unit microelectrode recordings and it is suggested that the representation in Area 3b is homologous to “SmI” (or “SI”) in non‐primates.

Somatosensory cortical map changes following digit amputation in adult monkeys

The cortical representations of the hand in area 3b in adult owl monkeys were defined with use of microelectrode mapping techniques 2–8 months after surgical amputation of digit 3, or of both digits