Progression of aortic valve stenosis: TGF-beta1 is present in calcified aortic valve cusps and promotes aortic valve interstitial cell calcification via apoptosis.

@article{Jian2003ProgressionOA,
  title={Progression of aortic valve stenosis: TGF-beta1 is present in calcified aortic valve cusps and promotes aortic valve interstitial cell calcification via apoptosis.},
  author={Bo Jian and Navneet R Narula and Quan-yi Li and Emile R. Mohler and Robert J. Levy},
  journal={The Annals of thoracic surgery},
  year={2003},
  volume={75 2},
  pages={457-65; discussion 465-6}
}
BACKGROUND Aortic valve stenosis characteristically progresses due to cuspal calcification, often necessitating valve replacement surgery. The present study investigated the hypothesis that TGF-beta1, a cytokine that causes calcification of vascular smooth muscle cells in culture, initiates apoptosis of valvular interstitial cells as a mechanistic event in cuspal calcification. METHODS Noncalcified and calcified human aortic valve cusps were obtained at autopsy or at the time of cardiac… CONTINUE READING
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