Progression of and recovery from pulmonary oxygen toxicity in humans exposed to 5 ATA air.

@article{Eckenhoff1987ProgressionOA,
  title={Progression of and recovery from pulmonary oxygen toxicity in humans exposed to 5 ATA air.},
  author={Roderic G. Eckenhoff and Jeffrey Dougherty and Arthur A. Messier and Steven Osborne and Joel Wm. Parker},
  journal={Aviation, space, and environmental medicine},
  year={1987},
  volume={58 7},
  pages={658-67}
}
Animal studies suggest that pulmonary oxygen toxicity proceeds more slowly in diluted oxygen breathing mixtures than in pure oxygen at the same inspired partial pressure. We exposed 12 healthy subjects to air at 5 ATA (PiO2 = 1.05 ATA) in a hyperbaric chamber for 48 h, and compared the rate of development of symptoms of O2 toxicity to rates seen in previous studies using 100% O2 at 1 ATA. Symptoms consisted of chest tightness, cough, substernal discomfort, exertional dyspnea, anorexia, nausea… CONTINUE READING