Progression of MRI markers in cerebral small vessel disease: Sample size considerations for clinical trials.

@article{Benjamin2016ProgressionOM,
  title={Progression of MRI markers in cerebral small vessel disease: Sample size considerations for clinical trials.},
  author={Philip Benjamin and Eva Anna Zeestraten and Christian Lambert and Irina Chis Ster and Owen Alan Williams and Andrew J Lawrence and Bhavini C. Patel and Andrew D. Mackinnon and Thomas R. Barrick and Hugh S. Markus},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={2016},
  volume={36 1},
  pages={228-40}
}
Detecting treatment efficacy using cognitive change in trials of cerebral small vessel disease (SVD) has been challenging, making the use of surrogate markers such as magnetic resonance imaging (MRI) attractive. We determined the sensitivity of MRI to change in SVD and used this information to calculate sample size estimates for a clinical trial. Data from the prospective SCANS (St George’s Cognition and Neuroimaging in Stroke) study of patients with symptomatic lacunar stroke and confluent… CONTINUE READING