Progression of Hip Dysplasia in Mucopolysaccharidosis Type I Hurler After Successful Hematopoietic Stem Cell Transplantation.

  title={Progression of Hip Dysplasia in Mucopolysaccharidosis Type I Hurler After Successful Hematopoietic Stem Cell Transplantation.},
  author={Eveline J. Langereis and Matthijs M den Os and Catherine Mary Breen and Simon A. Jones and O.C. Knaven and Jean Mercer and Weston P Miller and Paula Marie Kelly and Jim F Kennedy and Tyler G Ketterl and Anne O’Meara and Paul J. Orchard and Troy C Lund and Rick Robert van Rijn and Ralph J. B. Sakkers and Klane K White and F. A. Wijburg},
  journal={The Journal of bone and joint surgery. American volume},
  volume={98 5},
BACKGROUND Dysostosis multiplex contributes substantially to morbidity in patients with Hurler syndrome (mucopolysaccharidosis type I Hurler phenotype [MPS I-H]), even after successful hematopoietic stem cell transplantation (HSCT). One of the hallmarks of dysostosis multiplex in MPS I-H is hip dysplasia, which often requires surgical intervention. We sought to describe in detail the course of hip dysplasia in this group of patients, as assessed by radiographic analysis, and to identify… 

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