Progression of Alzheimer-type neurofibrillary tangles is related to the proximodistal segments of the hemispheric arteries.


In Alzheimer's disease (AD), neurofibrillary degeneration in the hemispheres starts in the limbic and paralimbic regions prior to those in the isocortical ones but factors determining the progression of these changes are unknown. Previous studies have shown that migration of extracellular substances (volume transmission) driven by arterial pulse pressure… (More)