Progression in Colon Cancer Cells microRNA-21 Negatively Regulates Cdc 25 A and Cell Cycle

@inproceedings{Wang2009ProgressionIC,
  title={Progression in Colon Cancer Cells microRNA-21 Negatively Regulates Cdc 25 A and Cell Cycle},
  author={Peng Wang and Fangdong Zou and Xiaodong Zhang and Hua Li and Austin Michael Dulak and Robert J. Tomko and John S Lazo and Zhenghe John Wang and Lin Zhang and Jian Yu},
  year={2009}
}
microRNAs (miRNA) are small noncoding RNAs that participate in diverse biological processes by suppressing target gene expression. Altered expression of miR-21 has been reported in cancer. To gain insights into its potential role in tumorigenesis, we generated miR-21 knockout colon cancer cells through gene targeting. Unbiased microarray analysis combined with bioinformatics identified cell cycle regulator Cdc25A as a miR-21 target. miR-21 suppressed Cdc25A expression through a defined sequence… CONTINUE READING

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