Progress towards validating the NMDA receptor hypofunction hypothesis of schizophrenia.

  title={Progress towards validating the NMDA receptor hypofunction hypothesis of schizophrenia.},
  author={Craig W Lindsley and William D Shipe and Scott Wolkenberg and Cory R. Theberge and David L Williams and Cyrille Sur and Gene G. Kinney},
  journal={Current topics in medicinal chemistry},
  volume={6 8},
This article describes recent progress towards validation of the N-methyl-D-aspartate (NMDA) receptor hypofunction hypothesis of schizophrenia in preclinical models. Schizophrenia, a complex disease characterized by positive, negative and cognitive symptoms, affects 1% of the world population and requires lifelong, daily maintenance therapy. For the last several decades, thinking in this field has been dominated by the hypothesis that hyperfunction of dopamine pathways played a key role in… CONTINUE READING
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