Progress towards an effective syphilis vaccine: the past, present and future

@article{Cullen2006ProgressTA,
  title={Progress towards an effective syphilis vaccine: the past, present and future},
  author={Paul A. Cullen and Caroline E. Cameron},
  journal={Expert Review of Vaccines},
  year={2006},
  volume={5},
  pages={67 - 80}
}
Syphilis is a disease caused by infection with the spirochetal pathogen Treponema pallidum subspp. pallidum. Despite intensive efforts, the unusual biology of T. pallidum has hindered progress towards the development of a vaccine to prevent infection. This review describes previous endeavors to develop a syphilis vaccine, outlines the key issues in the field and proposes new directions in the design of a T. pallidum vaccine. Following a brief overview of the disease symptoms, epidemiology… Expand
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