Progress towards a clinically-successful ATR inhibitor for cancer therapy

@inproceedings{Barnieh2021ProgressTA,
  title={Progress towards a clinically-successful ATR inhibitor for cancer therapy},
  author={F. M. Barnieh and P. Loadman and R. Falconer},
  year={2021}
}
Abstract The DNA damage response (DDR) is now known to play an important role in both cancer development and its treatment. Targeting proteins such as ATR (Ataxia telangiectasia mutated and Rad3-related) kinase, a major regulator of DDR, has demonstrated significant therapeutic potential in cancer treatment, with ATR inhibitors having shown anti-tumour activity not just as monotherapies, but also in potentiating the effects of conventional chemotherapy, radiotherapy, and immunotherapy. This… Expand

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