Progress toward oligonucleotide therapeutics: pharmacodynamic properties.

@article{Crooke1993ProgressTO,
  title={Progress toward oligonucleotide therapeutics: pharmacodynamic properties.},
  author={Stanley T Crooke},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={1993},
  volume={7 6},
  pages={
          533-9
        }
}
Although many issues remain to be resolved, recent progress suggests that oligonucleotides may have therapeutic potential. The first therapeutic oligonucleotide, ISIS 2105, an oligonucleotide designed to treat genital warts, has completed Phase I clinical trials and is undergoing Phase II testing. Conceptually, oligonucleotides may interact with nucleic acid or nonnucleic acid receptors; however, rational design of oligonucleotide drugs to interact with nucleic acid receptors is significantly… CONTINUE READING
BETA

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 22 CITATIONS