Progress report on the Canadian Multicentre Trial of tetrahydroaminoacridine with lecithin in Alzheimer's disease.

@article{Gauthier1989ProgressRO,
  title={Progress report on the Canadian Multicentre Trial of tetrahydroaminoacridine with lecithin in Alzheimer's disease.},
  author={Serge G. Gauthier and R L Bouchard and Y Bacher and Peter Bailey and Howard Bergman and L. S. Carrier and Roland Charbonneau and Mark A Clarfield and Brian Collier and D P Dastoor},
  journal={The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques},
  year={1989},
  volume={16 4 Suppl},
  pages={543-6}
}
Since the discovery of a significant depletion of acetylcholine in discrete areas of the brain of patients affected by Alzheimer's disease, attempts at symptomatic therapy have concentrated on acetylcholine supplementation, an approach that is based upon the efficacy of dopaminergic supplementation therapy for Parkinson's disease. Choline, then lecithin, used orally, failed to improve symptoms but the hypothesis that long-term choline supplementation might stabilize the course of Alzheimer's… CONTINUE READING