Progress on the relationship between miR-125 family and tumorigenesis.

  title={Progress on the relationship between miR-125 family and tumorigenesis.},
  author={Hang Yin and Yuqiang Sun and Xiaofeng Wang and Jeiyoun Park and Yuanyang Zhang and Molin Li and Jian Yin and Qiang Liu and Minghai Wei},
  journal={Experimental cell research},
  volume={339 2},
miRNA-125 family, which is a highly conserved miRNA family throughout evolution, is consist of miRNA-125a-3p, miRNA-125a-5p, miRNA-125b-1 and miRNA-125b-2.The aberrant expression of miR-125 familyis tightly related to tumorigenesis and tumor development. The downstream targets of miRNA-125 include transcription factors like STAT3, cytokines like IL-6 and TGF-β, tumor suppressing protein p53, pro-apoptotic protein Bak1 and RNA binding protein HuR et al. Through regulating these downstream… CONTINUE READING
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