Progress on the cardiotoxicity of sunitinib: Prognostic significance, mechanism and protective therapies.

@article{Yang2016ProgressOT,
  title={Progress on the cardiotoxicity of sunitinib: Prognostic significance, mechanism and protective therapies.},
  author={Yi Yang and Peili Bu},
  journal={Chemico-biological interactions},
  year={2016},
  volume={257},
  pages={125-31}
}
Tyrosine kinase inhibitors (TKIs) are multi-targeted anti-cancer agents effective in the treatment of renal cell carcinoma (RCC), imatinib-resistant gastrointestinal stromal tumor (GIST) and pancreatic cancer (PC). Targeting and inhibiting a wide range of oncogenically relevant receptor tyrosine kinases (RTKs), TKIs have been the golden standard treatment of several types of cancer. The cardiotoxicity of TKIs, however, has also emerged alongside their anti-cancer potencies and has attracted… CONTINUE READING