Progress on kinesin spindle protein inhibitors as anti-cancer agents.


The kinesin spindle protein (KSP, also known as Hs Eg5) plays an essential part in the proper separation of spindle poles and the correct formation of bipolar mitotic spindle during mitosis. Inhibition of this protein results in cells apoptosis followed by mitotic arrest and the formation of characteristic monoaster spindles. Compared with the traditional… (More)


Figures and Tables

Sorry, we couldn't extract any figures or tables for this paper.