Progress in xenotransplantation following the introduction of gene-knockout technology.

  title={Progress in xenotransplantation following the introduction of gene-knockout technology.},
  author={Hao-Chih Tai and Mohamed B Ezzelarab and Hidetaka Hara and David L. Ayares and David K C Cooper},
  journal={Transplant international : official journal of the European Society for Organ Transplantation},
  volume={20 2},
The production of alpha1,3-galactosyltransferase gene-knockout (GT-KO) pigs has overcome the barrier of preformed anti-Galalpha1,3Gal (Gal) antibodies that has inhibited progress in pig-to-primate organ xenotransplantation for many years. Survival of GT-KO pig organs in nonhuman primates is currently limited by the development of a thrombotic microangiopathy that results in increasing ischemic injury of the transplanted organ over weeks or months. Potential causative factors include vascular… CONTINUE READING


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