Progress in understanding the pathophysiology of cerebral ischemia: the almitrine-raubasine approach.

@article{BentuFerrer1990ProgressIU,
  title={Progress in understanding the pathophysiology of cerebral ischemia: the almitrine-raubasine approach.},
  author={Dani{\`e}le Bentu{\'e}-Ferrer and R. Decombe and Jean Michel Reymann and Christian Schatz and Herv{\'e} Allain},
  journal={Clinical neuropharmacology},
  year={1990},
  volume={13 Suppl 3},
  pages={S9-25}
}
Cerebral ischemia occurs frequently and is disabling. In addition to preventing and correcting risks factors, drugs prevent cell death induced by ischemia-hypoxia. Precise knowledge of the pathophysiology of cerebral ischemia is the prerequisite for drug development, and the main proofs of efficiency are histopathological and clinical (i.e., the results of controlled studies). Different animal models are considered valid for global, focal, or multifocal ischemia. These models have enabled the… CONTINUE READING