• DOI:10.1016/j.neuropharm.2017.12.032
Corpus ID: 3414348

Progress in understanding mechanisms of opioid-induced gastrointestinal adverse effects and respiratory depression

@article{Imam2018ProgressIU,
  title={Progress in understanding mechanisms of opioid-induced gastrointestinal adverse effects and respiratory depression},
  author={Mohammad Zafar Imam and A. Kuo and S. Ghassabian and M. Smith},
  journal={Neuropharmacology},
  year={2018},
  volume={131},
  pages={238-255}
}

Mohammad Zafar Imam, A. Kuo, +1 author M. Smith

Published 2018

Medicine

Neuropharmacology

ABSTRACT Opioids evoke analgesia through activation of opioid receptors (predominantly the &mgr; opioid receptor) in the central nervous system. Opioid receptors are abundant in multiple regions of the central nervous system and the peripheral nervous system including enteric neurons. Opioid‐related adverse effects such as constipation, nausea, and vomiting pose challenges for compliance and continuation of the therapy for chronic pain management. In the post‐operative setting opioid‐induced… CONTINUE READING

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