Progress in understanding mechanisms of opioid-induced gastrointestinal adverse effects and respiratory depression

  title={Progress in understanding mechanisms of opioid-induced gastrointestinal adverse effects and respiratory depression},
  author={Mohammad Zafar Imam and A. Kuo and S. Ghassabian and M. Smith},
  • Mohammad Zafar Imam, A. Kuo, +1 author M. Smith
  • Published 2018
  • Medicine
  • Neuropharmacology
  • ABSTRACT Opioids evoke analgesia through activation of opioid receptors (predominantly the &mgr; opioid receptor) in the central nervous system. Opioid receptors are abundant in multiple regions of the central nervous system and the peripheral nervous system including enteric neurons. Opioid‐related adverse effects such as constipation, nausea, and vomiting pose challenges for compliance and continuation of the therapy for chronic pain management. In the post‐operative setting opioid‐induced… CONTINUE READING
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